Louisville defeated James Madison 28-14 in Week 2, with the Cardinals pulling away in the fourth quarter. James Madison struck first, with Matthew Sluka connecting with Lacota Dippre for a touchdown in the first quarter to take an early 7-0 lead. Louisville answered with a field goal in the second quarter before extending its advantage in the third on a Miller Moss touchdown pass to Chris Bell covering 64 yards.

The Cardinals put the game away in the fourth quarter with a dominant 14-point performance. Isaac Brown's 78-yard touchdown run capped Louisville's offensive outburst. Despite a late interception of Sluka's pass by Jabari Mack, James Madison couldn't generate sufficient offense to threaten the outcome.

Sluka led James Madison's efforts with 35 passing yards and 83 rushing yards. For Louisville, Chris Bell led all receivers with 83 receiving yards. Louisville's defense made crucial stops throughout, particularly in the third and fourth quarters when the game was decided.

FINAL: Louisville 28, James Madison 14