Kansas defeated Oklahoma State 38-21 in Week 10, with the Jayhawks controlling the game throughout. Oklahoma State scored first with a touchdown pass from Z. Flores to S. Rigby in the first quarter, but Kansas responded decisively. The Jayhawks outscored the Cowboys 35-14 over the remaining three quarters, with particularly dominant performances in the third and fourth quarters when they scored 14 points each.

Oklahoma State's offense struggled despite some notable plays. Flores connected with T. Davis for a 29-yard completion in the fourth quarter and found G. Freeman for a touchdown in the third quarter. Gavin Freeman led Oklahoma State receivers with 78 yards. However, Kansas' defense made crucial stops throughout the game, with their fourth-quarter performance providing the most significant defensive plays of the contest.

Kansas' running game proved effective, with L. Williams rushing for 32 yards on a key fourth-quarter drive. The Jayhawks' balanced attack and strong defensive performance in the second half secured a convincing victory that also covered the 25-point spread.