Toledo cruised to a 45-21 victory over Western Kentucky in Week 2, with the Rockets' dominant first half setting the tone for the entire contest. Toledo scored 21 points in the opening quarter and added 10 more in the second to build an insurmountable lead. The home team outscored Western Kentucky 45-7 through three quarters before both teams went scoreless in the fourth.

Toledo's offense was fueled by several explosive plays, including a 71-yard touchdown pass from Tucker Gleason to Junior Vandeross III in the second quarter and a 75-yard rushing touchdown by Chip Trayanum in the third. John Alan Richter led Toledo's passing attack with 46 completions.

Western Kentucky mounted a fourth-quarter comeback attempt with 14 points, but it proved too little too late. Matthew Henry led the Hilltoppers with 9 receptions. An early turning point came when Maverick McIvor was intercepted by Emmanuel McNeil-Warren, who returned it 37 yards for a Toledo touchdown.

The game went over the 57.5-point over/under, and Toledo covered the 8.5-point spread.