UTSA edged Colorado State 17-16 in a defensive battle that saw the visitor overcome a fourth-quarter comeback attempt by the Rams. The Roadrunners scored 10 points in the second quarter before adding a touchdown in the fourth to secure the victory. Colorado State mounted a late charge with 13 fourth-quarter points, but fell just short of completing the comeback.

The game's pivotal moment came in the fourth quarter when UTSA's Owen McCown connected with Robert Henry Jr. on a 74-yard touchdown pass—the game's most impactful play by EPA. Colorado State's defense made several strong stops, highlighted by two defensive plays in the second and fourth quarters that limited UTSA's scoring opportunities.

Lloyd Avant led Colorado State's ground game with 96 rushing yards, while Armani Winfield paced the receiving corps with 93 yards for the Rams. Jackson Brousseau directed the Colorado State offense, completing 78 passing yards.

The low-scoring contest finished well under the 58.5 over-under, with UTSA's defense ultimately making the difference in Week 4.