South Alabama defeated Morgan State 38-21 in Week 1 of the 2025 season. The Jaguars controlled the game from start to finish, building a 17-7 halftime lead before pulling away in the second half with 21 combined points in the final two quarters.

Morgan State's Jason Collins Jr. led all rushers with 83 yards, while South Alabama's offense was paced by quarterback Jared Hollins and receiver Jeremy Scott, who each recorded 8 statistical units. The teams traded first-quarter scoring, with South Alabama's Bishop Davenport connecting with Anthony Eager on a 34-yard completion and Miller McCrumby on a 32-yard pass play, while Morgan State answered with a Kobe Muasau-to-Ferdinand Nyivih completion for 24 yards.

South Alabama's defense made critical plays throughout, including a pivotal fourth-quarter stop on a Randall Nauden run. Despite Morgan State's late-game efforts, including a 23-yard Muasau-to-Malique Leatherbury completion in the third quarter, the hosts' defensive pressure proved too much to overcome. The final margin exceeded the 28.5-point spread, and the combined 59 points surpassed the 51.5 over-under.